11/19/2022 0 Comments Biological age vs chronological age![]() BIOLOGICAL AGE VS CHRONOLOGICAL AGE CODEDNA determines our unique genetic code and provides the fundamentals for organisms to develop, survive and reproduce. We know this because yeast live for 6 days, flies for 2 months, mice for 2 years and humans for 70+ years. Genes are the master regulators when it comes to lifespan. BIOLOGICAL AGE VS CHRONOLOGICAL AGE HOW TOAlthough most doctors and scientists have never thought about why we age or how to treat aging directly, the current research indicates that we should. Sinclair proposes that the true cause of aging lies even further upstream of these nine hallmarks and is based on the loss of both DNA and epigenetic information. If we can address these hallmarks and slow down aging, we can prevent chronic diseases and extend healthspan and longevity. Altered intercellular communication and the production of inflammatory molecules.Accumulation of senescent cells (which inflame healthy cells).Deregulated nutrient sensing caused by metabolic changes.Loss of healthy protein maintenance, proteostasis.Alterations to the epigenome that controls which genes are turned on and off.Shortening of the protective chromosomal endcaps called telomeres.Genomic instability caused by DNA damage.David Sinclair’s book, Lifespan, he discusses nine hallmarks of aging that must be addressed in order to progress healthfully into old age. If aging is truly the root cause of all of these diseases then, can we prevent them by addressing aging head on? Researchers say yes, although pinpointing the true root cause of aging is not so simple. Although it seems that pain medication and chronic diseases are inevitable aspects of aging, the science implies a different story. In Alzheimer’s disease, unhealthy lifestyles such as poor diets, lack of exercise and lack of sleep can prevent the proper clearing of amyloid-beta and thus creates plaques and tangles in the brain, leading to neurodegeneration (2)(3)(4). When high amounts of saturated fat are consumed over the course of 10, 20 or 30+ years however, the body’s ability to clear out this accumulation of fat worsens and this plaque buildup in the arteries leads to atherosclerosis, strokes and cardiovascular diseases. For example, saturated fat in small amounts can be processed by the body and thus causes little to no harm. Throughout life our bodies accumulate toxins and DNA damage by unhealthy air quality, poor diets, sedentary lifestyles, high stress levels and poor sleep quality – all of which wear down our organs and make us more susceptible to disease. However, top aging researchers are proposing that aging should be considered a disease as it is the fundamental mechanism behind many diseases that we see today including cancer, osteoporosis, Parkinson’s, Alzheimer’s and heart disease (1). Aging, as we understand it, is a biological process and not a disease directly. ![]()
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